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Biological function does not have a unique scale, but is rather an interlaced property ranging from the macroscopic scale to the molecular and atomic level. We aim to understand biological function on a multi-level scales: the fundamental principles of protein and bio-molecular dynamics on the nano-scale, and the dynamic interactions in cellular networks giving rise to macroscopic function and behavior on the organism level. The success of this endeavor will critically depend on the development of new techniques and approaches, which represents a main focus of our research. As an experimental physicist with background in quantum information and quantum optics I have been trying to work towards this goal by using ultrafast and non-linear optics, molecular biology, genetic tools and electrophysiology techniques in an integrated fashion for developing new structural and functional imaging techniques such multilayer 3D super-resolution imaging and optogenetic tools with high spatiotemporal resolution for neuronal circuit mapping. Further, together with our collaborators we have recently started to investigate the function and the dynamics of transmembrane protein complexes such an ion-channels on picosecond timescales. Using optical methods and simulations we hope to develop a better understanding of the relevance of protein dynamics on such short timescales for the biological function.
Alipasha Vaziri |
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Alipasha Vaziri |
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